The Indian Institute of Science Education and Research Pune, in collaboration with the Indian Institute of Technology Bombay, has published innovative results in Small Methods, developing a new method for preparing metal nanoparticles based on "constrained dewetting" technology. This technique enables the production of high-density and highly uniform nanoparticles, providing more sensitive sensor solutions for biomedical detection and environmental monitoring.

The research team achieved precise control over nanoparticle size and spacing by applying restrictive conditions between a metal thin film and a PDMS layer. Project leader Dr. Atikur Rahman stated: "This technology is applied for the first time in metal thin film preparation, significantly improving the uniformity and stability of nanoparticles." Experiments confirmed that nanoparticles prepared by this method can detect chemical substances at concentrations as low as picomolar levels, with sensitivity far exceeding traditional methods.

The technology is applicable to various metals such as silver and gold and can achieve scalable production on different substrates. The researchers noted that this breakthrough will bring new technological possibilities to fields such as early disease diagnosis and environmental pollutant detection.