en.Wedoany.com Reported - A recent retrospective study published in Radiology evaluated the impact of AI-driven slice reconstruction technology on the screening performance of digital breast tomosynthesis (DBT). The study analyzed data from 119,662 screening DBT examinations performed on 64,949 women, using slice reconstruction technology (3DQuorum, Hologic) to provide 6 mm synthetic slices with 3 mm overlap. The study cohort included 77,577 DBT examinations from 52,649 women (mean age 60 years) before the implementation of the technology, and 42,085 DBT examinations from 42,059 women (mean age 60 years) after implementation.

Study results showed no statistically significant differences in sensitivity (85.9% vs 82.3%), cancer detection rate (6.5/1000 vs 5.8/1000), and false-negative rate (1.1/1000 vs 1.2/1000) with the use of AI-driven slice reconstruction technology.

However, the technology brought statistically significant performance improvements. After implementation, specificity increased from 94.4% to 94.9%, and the abnormal interpretation rate (AIR) decreased from 6.2% to 5.8%. In an interview with Diagnostic Imaging in 2025 during the RSNA annual meeting, the lead study author, Manisha Bahl, MD, MPH, FSBI, Associate Professor of Radiology at Harvard Medical School and breast radiologist at Massachusetts General Hospital, emphasized the clinical impact of the technology.

Dr. Bahl stated that after implementing 3DQuorum, recall rates were lower and specificity was higher, indicating that the technology can better distinguish between benign and malignant findings. The study noted that most participants were women aged 50 and older, but in a subgroup analysis of women under 50, the performance metrics of slice reconstruction technology showed no significant differences.

Subgroup analysis further indicated that the significant reduction in abnormal interpretation rate and improvement in specificity associated with slice reconstruction technology occurred only in women with scattered fibroglandular density in the breast. The researchers added that these findings suggest slice reconstruction technology provides greater benefits in older women and those with scattered fibroglandular density.

The authors acknowledged limitations of the study, including its single-center, retrospective design, with approximately 80% of the cohort being White women and about 3% having extremely dense breasts. Additionally, the slice reconstruction technology was used only with a single vendor's equipment, and image interpretation was performed by specialized breast radiologists with extensive DBT experience, which may limit the generalizability of the results.

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