en.Wedoany.com Reported - A research team at University College Dublin has found that cinquefoil extract can effectively inhibit a variety of pathogens, including drug-resistant bacteria, while preventing the formation of bacterial biofilms. When used in combination, it also enhances the efficacy of antibiotics such as colistin.

As the problem of antibiotic resistance becomes increasingly severe, traditional infection treatments face growing difficulties. Scientists have begun to focus on plant species that have accumulated defensive compounds over long periods of evolution.

The research team tested over 70 plant extracts for their inhibitory effects on various pathogens and their ability to prevent bacterial biofilm formation. The results showed that cinquefoil extract exhibited significant antibacterial activity and prevented biofilm formation, consistent with its use in traditional medicine.

Further studies revealed that when combined with antibiotics such as colistin, cinquefoil extract enhanced the effectiveness of the drugs. The researchers speculate that natural compounds in cinquefoil, such as ellagic acid and agrimoniin, may inhibit bacterial growth by limiting the bacteria's access to iron, which is essential for their growth.

The researchers noted that the rise in antimicrobial drug resistance is driving the industry to seek new solutions. Plants, as an underexplored natural resource, may provide entirely new antimicrobial agents or be used to enhance the efficacy of existing drugs. This study demonstrates how nature and traditional medicine can work in synergy with modern science to address contemporary antimicrobial challenges.

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