en.Wedoany.com Reported - Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd. (referred to as "Shandong Yonghao Pharmaceutical") issued an environmental impact assessment announcement in June 2026, planning to invest 20 million yuan to build a technical renovation project with an annual output of 2000 tons of 5-hydroxy-1-methyl-3-trifluoromethyl-1H-pyrazole within its existing plant area in the Chemical Industrial Park of Zhanhua Economic Development Zone, Shandong. The project will utilize the existing third workshop (with a building area of 750 square meters) and install 124 sets of equipment including condensation kettles, distillation kettles, neutralization kettles, cyclization kettles, and crystallization kettles. Using the ethyl trifluoroacetoacetate synthesis process, it is expected to produce 2000 tons of 5-hydroxy-1-methyl-3-trifluoromethyl-1H-pyrazole annually, along with 1250 tons of by-product ethanol.
Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd. was established on April 14, 2011, with its registered address in Binhai Chemical Park, Zhanhua District, Binzhou City, Shandong Province. It is a large-scale production base newly invested and built by Taizhou Yongfeng Chemical Co., Ltd. The company's main business covers the research, development, and production of pesticide intermediates and pharmaceutical intermediates, as well as the manufacturing of specialty chemicals such as ethyl trifluoroacetoacetate. As an enterprise deeply rooted in the fine chemical field, Shandong Yonghao Pharmaceutical leverages its parent company's technical accumulation in chemical synthesis to continuously extend its industrial chain towards high-value-added pesticide intermediates.
5-hydroxy-1-methyl-3-trifluoromethyl-1H-pyrazole is a key intermediate for synthesizing the herbicide pyroxasulfone. Pyroxasulfone belongs to the class of cell division inhibitor herbicides. It inhibits the biosynthesis of very long chain fatty acids (VLCFAs) in plants, thereby hindering the growth of meristems and coleoptiles, leading to weed death. This herbicide is primarily used in crop fields such as corn, soybeans, wheat, peanuts, cotton, sunflowers, and potatoes, effectively controlling annual weeds. With the continuous growth in global demand for highly efficient, low-toxicity, and selective herbicides, the market prospects for pyroxasulfone and its intermediates are relatively broad.
The project is located in the Binhai Chemical Park area of the Chemical Industrial Park in Zhanhua Economic Development Zone. Zhanhua Economic Development Zone is a provincial-level chemical park recognized by Shandong Province, focusing on the development of fine chemicals, new materials, and other industries, with well-established public utilities and environmental protection facilities. The project implements technical renovation within the company's existing plant area, fully utilizing existing auxiliary and environmental protection facilities to reduce investment costs. Upon completion, the project will help Shandong Yonghao Pharmaceutical further diversify its product structure and enhance its market competitiveness in the pesticide intermediate field, while the by-product ethanol will also bring additional economic benefits to the company.
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