en.Wedoany.com Reported - Two years after launching InmuOlive®, a feed additive based on olive pomace, Chilean startup AcuiOlive has accumulated multiple scientific evidences and defined concrete steps toward commercial validation. The product aims to improve fish health and performance in salmon farming, utilizing olive processing by-products to develop sustainable functional ingredients.
In October 2024, the company obtained Patent No. 69,896 from the National Institute of Industrial Property (INAPI) of Chile, valid until 2043. The patent protects the additive's preparation process, functional ingredient, feed containing the ingredient, and its use in fish, mammals, and poultry. In Chile, for the next 17 years, no company may use functional ingredients derived from olive pomace in fish feed without AcuiOlive's permission.
Recent achievements include industrial pellet validation conducted in collaboration with a domestic salmon farming company. Results showed that adding 2% InmuOlive® to the diet significantly enhanced the feed's antioxidant capacity. The trial used feed without astaxanthin to isolate the additive's effect. In actual production, additional synergistic effects are expected, as astaxanthin and InmuOlive® act through complementary and non-redundant pathways.
Plasma biomarker analysis conducted by the Animal Nutrition Laboratory of the University of Chile showed that, under three conditions—tanks not exposed to pathogens, pre-challenge fish populations, and fish actively infected with Piscirickettsia salmonis—those fed InmuOlive® exhibited higher levels of antioxidant defense indicators and lower markers of systemic oxidative damage. During the 38-day active infection period, fish in tanks fed InmuOlive® reached nearly the same body weight at the end of the trial as fish in uninfected tanks, indicating that the additive significantly buffered the metabolic cost of infection.
Dr. Cecilia Oñate, founder and director of AcuiOlive, noted that InmuOlive® acts not only as an antioxidant for pellets but also as a systemic enhancer of the antioxidant defense system, strengthening the fish's overall condition, with protective effects accumulating over time.
Next steps include validation trials in tanks under actual production conditions, monitoring biomarkers, production parameters, and fillet quality, including assessment of impact on melanosis. The biological pathway of melanosis directly aligns with InmuOlive®'s mechanism of action, and this issue affects a significant portion of fillets in the domestic industry. Trial designs are being developed jointly with key players in the salmon farming sector.
AcuiOlive is developing InmuOlive® Pro, a second-generation product based on sequential fermentation with additional microorganisms, aimed at enriching and refining the additive, with a focus on broodstock and pet food applications. The company is seeking strategic partners from the salmon farming and olive oil industries to co-develop this new product in exchange for favorable licensing conditions.
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